Fig. 2: The IC5 and IC7 associated with serum levels of SOD show significant group difference in two modalities. | Translational Psychiatry

Fig. 2: The IC5 and IC7 associated with serum levels of SOD show significant group difference in two modalities.

From: Multimodal neuroimaging reveals brain neurochemical disturbances associated with superoxide dismutase in first-episode drug-naïve schizophrenia

Fig. 2: The IC5 and IC7 associated with serum levels of SOD show significant group difference in two modalities.The alternative text for this image may have been generated using AI.

Spatial maps visualized at |Z| > 2.5, in which the positive Z-scores (warm regions) mean HC subjects > SCZ patients and the negative Z-scores (cool regions) mean HC subjects < SCZ (A). Violinplot of the loading parameters of IC5 and IC7 that were adjusted as HC subjects > SCZ on the mean of loadings. Note that * means significance passed FDR corrected for multiple comparison (number of components * number of modalities) (B). Loadings of IC5/IC7 and SOD levels were positively correlated, thus SCZ corresponds to lower SOD serum levels and lower loading weights compared to HC subjects (C). Note that blue and red dots refer to HC and SCZ, respectively. The gray regions indicate a 95% confidence interval. sMRI, structural MRI; fMRI, functional MRI; GMV, grey matter volume; ∗ denotes FDR corrected for multiple comparison.

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