Fig. 3: Ethanol-induced taurine increase in the nAc is not prevented by acute calcium treatment in naïve rats. | Translational Psychiatry

Fig. 3: Ethanol-induced taurine increase in the nAc is not prevented by acute calcium treatment in naïve rats.

From: The effects of sub-chronic calcium treatment on ethanol-induced dopamine elevation and the alcohol deprivation effect in the rat

Fig. 3

Time-course graphs of extracellular taurine levels in the nAc using reversed microdialysis following administration of (A) vehicle (Ringer’s solution) alone or in combination with ethanol (300 mM), and (B) CaCl2 (0.5 mM) alone or in combination with ethanol. Ethanol significantly increased the accumbal taurine levels compared to vehicle treated rats (A), and a significant difference in taurine levels was also observed between rats receiving CaCl2 alone compared with rats receiving the addition of ethanol (B). Bar graph of (C) accumbal taurine levels at time-point 60 min (20 min following the addition of ethanol) demonstrated a significant delay in the onset of ethanol-induced taurine elevation in the nAc in the presence of CaCl2. Arrows indicate time-points for drug administration. * denotes a significant effect by treatment. All data are presented as mean ± SEM. *p < 0.05, ***p < 0.001. CaCl2 calcium chloride, EtOH ethanol, nAc nucleus accumbens, Veh vehicle.

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