Fig. 5: An acute calcium injection does not evoke dopamine elevation in the nAc of rats repeatedly treated with calcium for ten days. | Translational Psychiatry

Fig. 5: An acute calcium injection does not evoke dopamine elevation in the nAc of rats repeatedly treated with calcium for ten days.

From: The effects of sub-chronic calcium treatment on ethanol-induced dopamine elevation and the alcohol deprivation effect in the rat

Fig. 5

A Basal extracellular levels of dopamine at time-point 0 presented as concentration in nM in the nAc of all rats pre-treated with either CaCl2 (73.5 mg/kg) or vehicle (0.9% NaCl) for ten days. B Time-course graphs of extracellular dopamine levels in the nAc in rats receiving an acute systemic i.p. injection of vehicle (0.9% NaCl) or CaCl2 (73.5 mg/kg). CaCl2 produced a significant dopamine increase in rats pre-treated with vehicle, but not in rats pre-treated with CaCl2 for 10 days. Arrow indicates time-point for drug administration. Legend name represents which pre- and acute treatment each group received. * denotes a significant result compared to vehicle. All data are presented as mean ± SEM. *p < 0.05. CaCl2 calcium chloride, i.p. intraperitoneal, nAc nucleus accumbens, ns non-significant, Veh vehicle.

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