Fig. 4: Perampanel exerts rapid antidepressant effects via reducing Grin2b expression. | Translational Psychiatry

Fig. 4: Perampanel exerts rapid antidepressant effects via reducing Grin2b expression.

From: Treatment with perampanel alleviates depression-like behavior in mice via modulating GluN2B expression to improve excitatory synaptic transmission

Fig. 4: Perampanel exerts rapid antidepressant effects via reducing Grin2b expression.The alternative text for this image may have been generated using AI.

A Schematic of perampanel injection after 1 h and behavioral testing. B Representative diagram of adenovirus injection. C Western blotting analysis of the Gri2B and Gria1 in mPFC of NCS, SCS, SshS, NshS and NshP group. (Grin2b: NCS: n = 3; SCS: n = 3; SshS: n = 3; NshS: n = 3; NshP: n = 3, NCS vs. SCS, welch’s t test, *p = 0.0189, t = 7.171; SCS vs. SshS, unpaired t test, *p = 0.0157, t = 4.030; NCS vs. NshS, welch’s t test, *p = 0.0176, t = 7.448; NshS vs. NshP, unpaired t test, *p = 0.0126, t = 4.305. Gria1: NCS: n = 3; SCS: n = 3; SshS: n = 3; NshS: n = 3; NshP: n = 3, NCS vs. SCS, welch’s t test, p = 0.6985, t = 0.4472; SCS vs. SshS, unpaired t test, *p = 0.0445, t = 2.891; NCS vs. NshS, welch’s t test, *p = 0.0205, t = 6.880; NshS vs. NshP, unpaired t test, *p = 0.0347, t = 3.146). D Social interaction ratio in social interaction test of NCS, SCS, SshS, NshS and NshP group. (NSC: n = 8; SCS: n = 6; SshS: n = 6; NshS: n = 6; NshP: n = 6, NCS vs. SCS, welch’s t test, *p = 0.0415, t = 2.395; SCS vs. SshS, unpaired t test, **p = 0.0097, t = 3.189; NCS vs. NshS, unpaired t test, p = 0.5944, t = 0.5469; NshS vs. NshP, unpaired t test, p = 0.5236, t = 0.6610). E Immobility time in force swimming test of NCS, SCS, SshS, NshS and NshP group. (NCS: n = 8; SCS: n = 6; SshS: n = 6; NshS: n = 6; NshP: n = 6, NCS vs. SCS, unpaired t test, *p = 0.0106, t = 3.023; SCS vs. SshS, unpaired t test, **p = 0.0047, t = 3.619; NCS vs. NshS, unpaired t test, p = 0.8263, t = 0.2243; NshS vs. NshP, unpaired t test, p = 0.8943, t = 0.1363). F Immobility time in tail suspension test of NCS, SCS, SshS, NshS and NshP group. (NCS: n = 8; SCS: n = 6; SshS: n = 6; NshS: n = 6; NshP: n = 6, NCS vs. SCS, unpaired t test, **p = 0.0086, t = 3.137; SCS vs. SshS, unpaired t test, *p = 0.0263, t = 2.605; NCS vs. NshS, unpaired t test, p = 0.6434, t = 0.4749; NshS vs. NshP, unpaired t test, p = 0.7086, t = 0.3845). G Total distances in open field test of NCS, SCS, SshS, NshS and NshP group. (NCS: n = 8; SCS: n = 6; SshS: n = 6; NshS: n = 6; NshP: n = 6, NCS vs. SCS, unpaired t test, p = 0.7699, t = 0.2993; SCS vs. SshS, unpaired t test, p = 0.5729, t = 0.5829; NCS vs. NshS, unpaired t test, p = 0.5214, t = 0.6606; NshS vs. NshP, unpaired t test, p = 0.5559, t = 0.6093).

Back to article page