Fig. 7: Perampanel’s antidepressant efficacy lasts for 12 h in mice. | Translational Psychiatry

Fig. 7: Perampanel’s antidepressant efficacy lasts for 12 h in mice.

From: Treatment with perampanel alleviates depression-like behavior in mice via modulating GluN2B expression to improve excitatory synaptic transmission

Fig. 7: Perampanel’s antidepressant efficacy lasts for 12 h in mice.The alternative text for this image may have been generated using AI.

A Schematic of the CSDS paradigm. B Social interaction ratio in social interaction test of Naïve, Res and Sus group mice. (Naïve: n = 8; Res: n = 9; Sus: n = 18, one-way ANOVA: Naïve vs. Res p = 0.7954, Naïve vs. Sus ****p < 0.0001, Res vs. Sus ****p < 0.0001; F (2, 32) = 37.82). C Schematic of perampanel injection after 12 h and SI behavioral testing. D Social interaction ratio in social interaction test of Naïve, Sus and SP0.5 group mice. (Naïve: n = 8; Sus: n = 9; SP0.5: n = 9, one-way ANOVA: Naïve vs. Sus, ***p = 0.0003, Naïve vs. SP0.5, **p = 0.0044, Sus vs. SP0.5, p = 0.7448; F (2, 23) = 12.16). E Pie chart of SI ratio. F Schematic of perampanel injection after 12 h and SI behavioral testing of SP-pre and SP-post. G Social interaction ratio in social interaction test of SP-pre and SP-post group mice. (SP-pre: n = 9; SP-post: n = 9, paired t test, **p = 0.0063, t = 3.666).

Back to article page