Table 1 Descriptive Information on the Chronic Alcohol Use Samples Used in the Study.

From: Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use

Attribute

Human

Primates

Mice

n

60

32

53

22

68

Age

40–73 years

NA

4–11 years

18 weeks

N/A

Sex

76.66% Male

93.75% Male

100% Male

100% Male

50% Male

Ethnicity / Strain

93.3% Caucasian

NA

NA

C57BL/6 J

S27 HDID-1

Phenotype

AUD

AUD

Heavy Drinking; Binge Drinking

CIE; Self-Admin;

Binge Drinking

Very Heavy Drinking

CIE + Self-Admin

Data Type

RNA-sequencing

Microarray

Microarray

Microarray

RNA-sequencig

Brain Regions

sPFC; NAc; CeA

sPFC

PFC; NAc; CeA

PFC; NAc; CeA

NAc

PMI / Sample Collection

32.8 h (13.8)

NA

NA

24 h After Last Session

3 Weeks After Last Session

PMID

31477794

22302827

28247455; 33942443

32469986

28442218

SRA # / GEO # / link

PRJNA530758; PRJNA551775

https://utexas.app.box.com/s/ddiy0zrj810zyxmg9y55bkk589v59sbo

GSE96731; GSE96732;

GSE143419

PRJNA380430

PRJNA551908

GSE144783

  1. sPFC superior pre-frontal cortex, NAc nucleus accumbens; Ce A Central Nucleus of the Amygdala, AUD alcohol use disorder, CIE chronic intermittent ethanol, Self-Admin ethanol self-administration, PMI post-mortem interval, S27 HDID-1 high drinking in the dark strain (27th generation of selective breeding). Primates = rhesus macaques. NA not available.