Table 2 Clinical characteristics of in-house datasets consisting schizophrenia spectrum disorders patients (n = 186).

From: Normative age-related structural brain deviations underlying psychopathology, cognitive impairment and neurological soft signs in schizophrenia spectrum disorders

Clinical Parameter

whiteCAT n = 74

NSS n = 112

Mann-Whitney U test (p-values)

Duration of Illness

10.69 (SD=10.19)

10.31 (SD=10.76)

n.s.

PANSS Total score

65.4 (SD=16.16)

67.42 (SD=21.46)

n.s.

PANSS Positive score

15.89 (SD=5.66)

15.65 (SD=6.97)

n.s.

PANSS Negative score

16.76 (SD=6.84)

16.69 (SD=7.37)

n.s.

PANSS General score

32.79 (SD=7.66)

35.17 (SD=10.99)

n.s.

NSS Total score

19.96 (SD=8.43)

18.93 (SD=8.2)

n.s.

NSS Motor Coordination

7.17 (SD=4.21)

7.47 (SD=3.8)

n.s.

NSS Integrative Functioningb

4.46 (SD=1.85)

2.6 (SD=1.5)

>0.001

NSS Complex motor tasks

3.33 (SD=1.81)

3.37 (SD=2.25)

n.s.

NSS Spatial Orientationa

3.51 (SD=2.77)

2.56 (SD=2.38)

0.02

NSS Hard Signs

3.28 (SD=2.14)

2.93 (SD=1.75)

n.s.

TMT-B

100.99 (SD=63.73)

111.72 (SD=65.72)

n.s.

DSSTb

59.04 (SD=19.62)

49.88 (SD=26.87)

0.005

CF

20.65 (SD=6.58)

18.43 (SD=13.12)

n.s.

  1. The clinical battery consisting of PANSS, NSS and cognitive tests were collected on SSD patients (whiteCAT and NSS cohorts) only.
  2. PANSS Positive and Negative Syndrome Scale; NSS Neurological Soft Signs; DSST Digit Symbol Substitution Test; TMT-B, Trail Making Test B; CF Categorical Fluency.
  3. a Indicate variables that are significantly different between datasets using Mann-Whitney U tests.
  4. b Indicate variables that survive the FDR correction. Significant differences between the datasets were found in DSST (U = 4950.5, p = 0.005, q = 0.04; rank-biserial r = −0.25) and NSS Integrative (U = 6255.0, p = 3.26 × 10⁻¹¹, q = 4.57 × 10⁻¹⁰; r = −0.57). The NSS Spatial subscore was nominally significant (U = 4785.0, p = 0.02, r = −0.02) but did not survive FDR correction (q = 0.09).”
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