Table 1 Kinase selectivity profile of compounds.
Kinase | IC50 (nmol/L) | ||
|---|---|---|---|
DW14383 | TAS-120 | AZD4547 | |
FGFR1 | <0.3 | 3.9 ± 0.8 | 0.4 ± 0.1 |
FGFR2 | 1.1 ± 0.3 | 4.2 ± 0.0 | 1.0 ± 0.5 |
FGFR3 | <0.3 | 8.1 ± 0.9 | 2.3 ± 0.2 |
FGFR4 | 0.5 ± 0.1 | 4.1 ± 1.2 | 49.8 ± 5.4 |
KDR | 335.8 ± 25.2 | >1000 | 57.9 ± 22.1 |
VEGFR-1 | >100 | >100 | >100 |
PDGFR-α | >1000 | >100 | >1000 |
PDGFR-β | >100 | >100 | >1000 |
C-Kit | >100 | >100 | >100 |
Flt-3 | >1000 | >100 | >1000 |
EGFR | >1000 | >1000 | >1000 |
ErbB2 | >1000 | >100 | >1000 |
ErbB4 | >100 | >100 | >1000 |
c-Src | >1000 | >1000 | >1000 |
ABL | >1000 | >1000 | >1000 |
EPH-A2 | >1000 | >1000 | >1000 |
IGFIR | >100 | >100 | >1000 |
