Fig. 6: PB exerts anticancer activity by inhibiting the HMGCR-mediated pathway. | Acta Pharmacologica Sinica

Fig. 6: PB exerts anticancer activity by inhibiting the HMGCR-mediated pathway.

From: Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction

Fig. 6

a The interaction between PB and HMGCR was determined by SPR assay. b–c A-375 and SK-MEL-5 cells were treated with the indicated concentrations of PB for 24 h or with 2 μM PB for different lengths of time. Western blotting analysis was applied to detect the expression levels of HMGCR, YAP and p-YAP. β-actin served as a loading control. Data are shown as the mean ± SEM of three independent experiments. *P < 0.05, **P < 0.01 vs. the control group.

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