Fig. 5: Structural basis for the interaction of FXR with GW4064 and its derivatives. | Acta Pharmacologica Sinica

Fig. 5: Structural basis for the interaction of FXR with GW4064 and its derivatives.

From: FXR: structures, biology, and drug development for NASH and fibrosis diseases

Fig. 5: Structural basis for the interaction of FXR with GW4064 and its derivatives.The alternative text for this image may have been generated using AI.

a Chemical structures of GW4064 and its derivatives. b The structure of FXR is bound with GW4064. PDB: 3DCT; FXR is in slate blue, and GW4064 is in magenta. c Overlay of GW4064 (magenta), GSK8062 (cyan), and GSK2324 (green). The hydrogen bonds are shown as red dashes (GSK8062) and yellow dashes (GSK2324). PDB codes are the following: 3DCT (FXR/GW4064), 3DCU (FXR/GSK8062), and 3P89 (FXR/GSK2324).

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