Fig. 3: Cynaropicrin affected p-AKT, AKT, p-ERK1/2, ERK1/2, and c-Myc expression as well as c-Myc transcriptional activity. | Acta Pharmacologica Sinica

Fig. 3: Cynaropicrin affected p-AKT, AKT, p-ERK1/2, ERK1/2, and c-Myc expression as well as c-Myc transcriptional activity.

From: Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma

Fig. 3: Cynaropicrin affected p-AKT, AKT, p-ERK1/2, ERK1/2, and c-Myc expression as well as c-Myc transcriptional activity.

a Effect of cynaropicrin at different concentrations on the protein expression levels of p-AKT, AKT, p-ERK1/2, ERK1/2, and STAT3 in AMO1 cells as detected by Western blotting. b Effect of cynaropicrin on the protein expression levels of c-Myc in AMO1 and HEK293 cells as detected by Western blotting. The bar diagrams were obtained by calculating the mean value ± SD of three experiments performed at different time points. c Effect of cynaropicrin and the known c-Myc inhibitor 10058-F4 on c-Myc transcriptional activity as percentage of the normalized HEK293 cells transiently transfected with c-Myc luciferase reporter construct. The bar diagram was obtained by calculating the mean value ± SD of two independent experiments with three replicates each. *P < 0.05, **P < 0.01, ***P < 0.001 if compared to control sample.

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