Table 2 IC50 values of cynaropicrin in MM, drug-sensitive and multidrug-resistant P-glycoprotein-overexpressing leukemia cells, and normal leukocytes.

From: Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma

Cell type

Cell line

IC50 (µM)

Multiple myeloma

AMO1

1.8 ± 0.3

JJN3

2.1 ± 0.7

L363

2.5 ± 0.3

MOLP8

2.5 ± 0.3

OPM2

2.6 ± 0.6

NCI-H929

2.7 ± 0.2

RPMI8226

2.7 ± 0.4

KMS11

2.8 ± 0.3

KMS12BM

3.2 ± 0.2

Leukemia

CCRF-CEM

2.9 ± 0.0

CEM/ADR5000

2.6 ± 0.2

Normal leukocytes

PBMCs- Donor 1

39.3 ± 1.4

Back to article page