Table 3 Validation of IC50 values using a narrower concentration range in four MM cell lines: AMO1, JJN3, OPM2, and L363 and in PBMCs collected from three different donors.

From: Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma

Cell type

Cell line

IC50 (µM)

Multiple myeloma

AMO1

1.8 ± 0.2

JJN3

1.9 ± 0.4

OPM2

2.3 ± 0.5

L363

2.6 ± 0.6

Normal leukocytes

PBMCs- Donor 2

28.4 ± 3.8

PBMCs- Donor 3

24.9 ± 7.8

PBMCs- Donor 4

22.0 ± 4.5

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