Fig. 1: In DO mice, AC-triggered cardiotoxicity shared similar characteristics with clinical patients, and significant individual variabilities were also observed. | Acta Pharmacologica Sinica

Fig. 1: In DO mice, AC-triggered cardiotoxicity shared similar characteristics with clinical patients, and significant individual variabilities were also observed.

From: HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

Fig. 1

a The schematic diagram showed DO mice grouping and the dosages of AC administrations. ECGs (b) and the levels of CK-MB (c) in AC-sensitive and AC-tolerant mice were measured after treatments of AC (n = 5). Cardiotoxicity-related behavior scores (d) and the coefficient of dispersion (e) of DO mice were recorded on the d 1. f The proportion of sensitive and tolerant mice at three dosages of AC. (*P < 0.05, **P < 0.01).

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