Fig. 8: SHH expression in clinical tissue samples is positively correlated with HNF1A. | Acta Pharmacologica Sinica

Fig. 8: SHH expression in clinical tissue samples is positively correlated with HNF1A.

From: Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer

Fig. 8

a Different colors represented box plots of the data normalized for different GEO NSCLC data sets. b The PCA results before batch removal showed two separate data sets without any intersection. c The PCA results after batch removal showed that some data intersected together for subsequent analysis. d Results of two gene correlation analyses in the intersecting data. e Results of correlation analysis of two genes in the TCGA NSCLC dataset. f IHC staining for HNF1A and SHH was performed on two independent tumor microarrays (TMA1 and TMA2). Images of representative cases with strong or weak expression of HNF1A and SHH in TMA1 were enlarged in the figure. g Correlation analysis of the average optical density values of IHC staining for two genes in TMA1 and TMA2. Damaged samples were not considered for scoring. h Kaplan–Meier plot of post-progression survival in NSCLC patients receiving chemotherapy stratified by HNF1A expression status.

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