Fig. 2: NGR1 enhances intestinal barrier in colitis mice. | Acta Pharmacologica Sinica

Fig. 2: NGR1 enhances intestinal barrier in colitis mice.

From: Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Fig. 2

a Colonic pathological injury was examined by AB-PAS staining. Scale bar = 50 μm. b Quantitative analysis of goblet cells. c The FITC-dextran fluorescence intensity in serum was measured by microplate reader (n = 4–5). d, e DAO and LPS in serum, examined by ELISA. Each bar represents the mean ± SD (n = 6 per group). f Representative ZO-1 and Occludin immunofluorescence-stained sections of colonic tissue (scale bar = 100 μm). g, h Relative fluorescence intensity statistics of ZO-1 and Occludin (n = 3 per group). i mRNA expression levels of ZO-1 and Occludin (n = 4 per group). Each bar represents the mean ± SD. ##P < 0.05, ###P < 0.001 vs. Control group; *P < 0.05, **P < 0.01, ***P < 0.001 vs. DSS group.

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