Fig. 4: NGR1 protects against the damage of Lgr5+ intestinal stem cell induced by DSS. | Acta Pharmacologica Sinica

Fig. 4: NGR1 protects against the damage of Lgr5+ intestinal stem cell induced by DSS.

From: Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Fig. 4

a Heatmaps of proliferation associated and stem cell-associated genes (n = 6 per group). b Representative Lgr5 immunofluorescence-stained sections of colonic tissue (scale bar = 50 μm). c Representative budding diagram of intestinal crypt Organoid, and the number of Organoid buds was counted and presented. (scale bar = 200 μm) (n = 3 per group). d Representative Lgr5 immunofluorescence-stained sections of Organoid. Scale bar = 200 μm. e–g Effects of NGR1 on the expression of Lgr5, Olfm4, Ascl2, Muc2, Lyz1, Gip, Sglt1, Vill-1, and Sis mRNA in Organoid (n = 4 per group). Each bar represents the mean ± SD. ###P < 0.001 vs. Control group; *P < 0.05, **P < 0.01, ***P < 0.001 vs. DSS group.

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