Fig. 7: ICG-001 inhibites the activation of Wnt/β-Catenin signaling by NGR1. | Acta Pharmacologica Sinica

Fig. 7: ICG-001 inhibites the activation of Wnt/β-Catenin signaling by NGR1.

From: Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Fig. 7

a Changes in body weight in mice of each group. The data were plotted as a percentage of the weight at baseline. Each bar represents the mean ± SD (n = 6 per group). b Colonic-length changes in mice of each group. Each bar represents the mean ± SD (n = 5–6 per group). c Colonic pathological injury was examined by H&E staining and AB-PAS staining. Scale bar = 50 μm. d Histology scores were counted and presented. e Quantitative analysis of goblet cells. f The fluorescence intensity of FITC-dextran was detected by fluorescence spectroscopy. Each bar represents the mean ± SD (n = 3–6 per group). g The mice body weight changes were monitored throughout the study. Each bar represents the mean ± SD (n = 8–9 per group). h Tumors were taken out after sacrifice of animal. i Tumor volume was measured during the test period. Each bar represents the mean ± SD (n = 8–9 per group). j Tumor weights were measured after the sacrifice of animal. Each bar represents the mean ± SD (n = 8–9 per group). *P < 0.05, **P < 0.01, ***P < 0.001 vs. DSS group.

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