Fig. 5: Vinorelbine plasma pharmacokinetic results in CES2-modified mouse models. | Acta Pharmacologica Sinica

Fig. 5: Vinorelbine plasma pharmacokinetic results in CES2-modified mouse models.

From: Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice

Fig. 5

Plasma concentration-time curves and AUC0–4h of vinorelbine and its metabolite deacetylvinorelbine in male wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V mice over 4 h after oral administration (a–d) or intravenous injection (e–h) of 10 mg/kg vinorelbine. Data are given as mean ± SD (n = 6–7). *, P < 0.05; ***, P < 0.001 compared to wild-type mice. ##, P < 0.01; ###, P < 0.001 compared to Ces2–/– mice. Statistical analysis was applied after log-transformation of linear data.

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