Fig. 6: Basic physiological analysis of the CES2 mouse models. | Acta Pharmacologica Sinica

Fig. 6: Basic physiological analysis of the CES2 mouse models.

From: Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice

Fig. 6

Body weight development from 4 to 20 weeks of age for females (a) and males (b); representative images of gonadal white adipose tissue of male mice from each mouse strain (c) and semi-quantified gonadal white adipose tissue adipositis levels (d) of 20-week-old wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V mice after body weight measurement from 4 weeks to 20 weeks of age. Data are given as mean ± SD (n = 19–20). *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared to wild-type mice. #, P < 0.05; ##, P < 0.01; ###, P < 0.001 compared to Ces2–/– mice. ^, P < 0.05; ^^, P < 0.01; ^^^, P < 0.001 for comparison between Ces2–/–A and Ces2–/–V mice. Statistical analysis was applied after log-transformation of linear data. For the scoring criteria in panel (d), please refer to the supplementary methods section 2.5.1; the Kruskal-Wallis rank test was used.

Back to article page