Fig. 7: Lipid disposition, metabolism and homeostasis in the CES2 mouse models. | Acta Pharmacologica Sinica

Fig. 7: Lipid disposition, metabolism and homeostasis in the CES2 mouse models.

From: Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice

Fig. 7

Semi-quantified Oil-red-O staining lipid droplet levels (a) and representative Oil-red-O staining images for liver lipid accumulation for each mouse strain (b) in male wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V 20-week old mice (n = 19–21; body weight of each individual mouse presented is indicated); (c) liver lipid contents in male wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V 20-week old mice (n = 8); (d) plasma triglyceride basal concentration (overnight fast) before very low-density lipoprotein (VLDL) production and secretion and oral lipid tolerance test in male wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V 12-week old mice (n = 20–24); (e) VLDL production and secretion and (f) oral lipid tolerance test in male wild-type, Ces2-/-, Ces2-/-A and Ces2-/-V 12-week old mice (n = 10–12). Data are given as mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared to wild-type mice. #, P < 0.05; ##, P < 0.01; ###, P < 0.001 compared to Ces2-/- mice. ^^, P < 0.01; for comparison between Ces2–/–A and Ces2–/–V mice. Statistical analysis was applied after log-transformation of linear data. For the scoring criteria in panel (a), please refer to the supplementary methods section 2.5.2; the Kruskal-Wallis rank test was used.

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