Fig. 8: Glucose metabolism and homeostasis in the CES2 mouse models. | Acta Pharmacologica Sinica

Fig. 8: Glucose metabolism and homeostasis in the CES2 mouse models.

From: Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice

Fig. 8

The plasma glucose concentration time curve (a), plasma glucose concentration to basal glucose concentration (before glucose administration) ratio time curve (b) and glucose AUC0-3h (c) in male wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V 12-week old mice over a 3 h glucose tolerance test after oral administration of 1 mg/g glucose; The plasma glucose concentration time curve (d), plasma glucose concentration to basal glucose concentration (before insulin injection) ratio time curve (e) and glucose AUC0-3h (f) in male wild-type, Ces2–/–, Ces2–/–A and Ces2–/–V 16-week old mice over a 3-h insulin tolerance test after i.p. injection of 0.5 U/kg insulin. Data are given as mean ± SD (n = 15–16). *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared to wild-type mice. #, P < 0.05; ##, P < 0.01; ###, P < 0.001 compared to Ces2–/– mice. Statistical analysis was applied after log-transformation of linear data.

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