Fig. 1: The decreased expression of hepatic CB2R in HFD induced NAFLD mice. | Acta Pharmacologica Sinica

Fig. 1: The decreased expression of hepatic CB2R in HFD induced NAFLD mice.

From: Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism

Fig. 1: The decreased expression of hepatic CB2R in HFD induced NAFLD mice.

a The body weight and food intake of WT mice with NCD or HFD throughout the experimental period were recorded. b The Representative images (200×) of H&E or Oil red O staining, and the morphometric analysis of Oil red O staining for quantification. c The comparison of serum levels of transaminases (ALT, AST) and lipid parameters (TG, TC), and blood glucose between WT mice with NCD or HFD. d The comparison of liver homogenate levels of TG. e Immunohistochemically labeled with CB2R of mice liver sections and quantitative analysis (200×, 400×). Note: Data were given as mean ± SEM. n: (a), n = 8 per group; (b), n = 4 per group; (c, d), n = 6 per group; (e), n = 3 per group. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. NCD normal control diet, HFD high fat diet, WT wild type, CB2R cannabinoid-2 receptor, NAFLD nonalcoholic fatty liver disease, H&E hematoxylin & eosin, ALT alanine transaminase, AST aspartate transferase, TC total cholesterol, TG triglyceride, SEM standard error of mean.

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