Fig. 10: CB2R-mediated gut dysbiosis contributed to NAFLD development in association with tryptophan metabolites. | Acta Pharmacologica Sinica

Fig. 10: CB2R-mediated gut dysbiosis contributed to NAFLD development in association with tryptophan metabolites.

From: Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism

Fig. 10: CB2R-mediated gut dysbiosis contributed to NAFLD development in association with tryptophan metabolites.

a Correlation network showed that gut dysbiosis in CB2R–/– mice was related to dysregulation of tryptophan metabolites, which were associated with parameters reflecting the severity of NAFLD including oil red positive area and body weight. b Correlation network between tryptophan metabolites and serum liver marker in CB2R–/– mice. n: (a, b), n = 4 per group.

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