Fig. 7: The microbial community of CB2R-/- mice with NCD was similar to HFD-induced NAFLD mice. | Acta Pharmacologica Sinica

Fig. 7: The microbial community of CB2R-/- mice with NCD was similar to HFD-induced NAFLD mice.

From: Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism

Fig. 7: The microbial community of CB2R-/- mice with NCD was similar to HFD-induced NAFLD mice.

a The microbial richness and diversity in feces of mice were depicted according to α-diversity parameters including Chao 1, observed_feature and Shannon and Simpson index. b The β-diversity was presented by PCoA plots. c LEfSe analysis showed the microbes with significant differences between WT mice with CB2R-/- mice with NCD. d The differential microbial structure at phylum level among three groups; Comparison of microbes at (e) family and (f) genus levels. The pathway enrichment analysis between WT mice feeding with NCD with (g) WT mice feeding with HFD or (h) CB2R–/– mice feeding with NCD was performed based on the predicted functional composition of microbial community. Note: Data were given as median with range. n: (a–h), n = 4 per group. *P < 0.05; **P < 0.01 and ***P < 0.001.

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