Fig. 9: Disordered tryptophan metabolism in CB2R–/– mice. | Acta Pharmacologica Sinica

Fig. 9: Disordered tryptophan metabolism in CB2R–/– mice.

From: Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism

Fig. 9: Disordered tryptophan metabolism in CB2R–/– mice.

a Three-dimensional score of PCA and two-dimensional score of OPLS-DA model based on the data of serum metabolic profiles of WT mice with NCD or CB2R–/– mice with NCD. b The pathway enrichment analysis of differential metabolites between WT mice with NCD and CB2R-/- mice with NCD, (c) and the clustering heat map of the differential tryptophan metabolites. The tryptophan metabolites belong to (d) kynurenine pathway, (e) serotonin pathway and (f) indole and its derivatives were compared between CB2R–/– mice with NCD and WT mice with HFD. g Alterations of tryptophan metabolic pathways in the CB2R–/– mice. The detected tryptophan metabolites in the current study were marked with a white color and underlined. Note: Data were given as medians with range or log2 fold change compared with wild type mice with NCD. n: (a–g), n = 4 per group. Trp tryptophan, KYN kynurenine, AA anthranilic acid, 3-HK 3-hydroxykynurenine, KYNA kynurenic acid, Xa xanthurenic acid, 3-HAA 3-hydroxyanthranilic acid, NA nicotinic acid, QUIN quinolinic acid, PIC picolinic acid, 5-HTP L-5-hydroxytryptophan, 5-HT serotonin, 5-Me-IAA 5-methoxy-3-indoleacetic, IPYA indole-3-pyruvic acid, IAOx indole-3-acetaldoxime, IS Indoxylsulfate, 5-HI 5-Hydroxyindole, ILA indolelactic acid, IAN indole-3-acetonitrile, IAAID indoleacetaldehyde, IAA indole-3-acetic acid, IAID indole-3-carboxaldehyde.

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