Fig. 6: Lipin1 enhances the responsiveness of myeloma cells to SEL in vivo. | Acta Pharmacologica Sinica

Fig. 6: Lipin1 enhances the responsiveness of myeloma cells to SEL in vivo.

From: Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma

Fig. 6

a The timeline and procedures for animal experiments (n = 20, n = 5/group); BIW: twice weekly, OG: oral gavage. The image was created using BioRender. b Tumor growth curves in different groups. c Photographic images of terminal tumor xenografts from each group. d Quantification of the tumor volume in terminal xenograft from different groups. e Quantification of the tumor weights of terminal xenograft in different groups. f Immunohistochemical staining of apoptosis marker cleaved caspase-3 and proliferation marker Ki67 expression in xenograft tumor tissues. Scale bar: 50 μm. Data are shown as mean ± SD; The statistical significance for the above data is indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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