Fig. 7: Altered transcriptional profile in the cortex of Satb1 mutant rats. | Acta Pharmacologica Sinica

Fig. 7: Altered transcriptional profile in the cortex of Satb1 mutant rats.

From: A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations

Fig. 7: Altered transcriptional profile in the cortex of Satb1 mutant rats.

a Scheme of the RNA-seq experiment. b Volcano plot of Satb1 mutant rats vs. WT control rats. c Gene Ontology analysis of differentially expressed genes between Satb1 mutant rats and WT control rats. d Venn diagrams identifying the overlap between DEGs and NDD/synaptosome gene databases. e, f Verification of the alterations in the genes involved in NDDs/synaptosomes and neuron-related pathways. n = 3 rats in each group. Student’s t test. *P < 0.05, **P < 0.01, and ***P < 0.001.

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