Fig. 6: Combination therapy with DAC and CDDP enhances antitumor immune efficacy. | Acta Pharmacologica Sinica

Fig. 6: Combination therapy with DAC and CDDP enhances antitumor immune efficacy.

From: DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity

Fig. 6

a Schematic illustrating the administration of DAC and CDDP for tumor treatment in CT26 tumor-bearing BALB/c mice. b The tumor growth curve was plotted (n = 5), and the tumor weight at the end of the experiments was shown. Error bars represent the mean ± SEM. c Schematic illustrating the administration of DAC and CDDP for tumor treatment in 4T1 tumor-bearing BALB/c mice. d The tumor growth curve was plotted (n ≥ 6), and the tumor weight at the end of the experiments was shown. Error bars represent the mean ± SEM. e Representative IHC images of CD3 or CD8 (left) and quantitative analysis (right) from 4T1 tumors. Significance was determined by unpaired Student’s t test. *P < 0.05, **P < 0.01; ***P < 0.001, ns no significant difference.

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