Correction: magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling

Correction to: Acta Pharmacologica Sinica https://doi.org/10.1038/s41401-018-0194-4, published online 19 December 2018

The authors regret to report errors in the paper published. We found unintentional misassembly of HE, Masson and Sirius red images in Fig. 1e, Immunohistofluorescence of E-Cadherin and N-Cadherin images iśn Fig. 2b, Vimentin images in Fig. 3d, mismarked groups in Fig. 3b and 3d, and mismarked statistical significance levels in Fig. 9c. These wrong images and information are replaced by right ones of the same batch. However, these errors will not affect the correctness of the results of the paper.

The correct data were shown below:

Fig. 1e

e Representative images of H&E-stained (scale bar, 50 μm), Masson-stained (scale bar, 100 μm) and Sirius red-stained (scale bar, 100 μm) paraffin-embedded sections of liver tissues are shown.

Fig. 2b

b Immunohistofluorescence analysis of E-Cadherin (red) and N-Cadherin (green) in rat liver sections. Representative images are shown (scale bar, 75 μm).

Fig. 3b, 3d

Magnesium isoglycyrrhizinate attenuates high fructose-induced EMT in BRL-3A cells and primary rat hepatocytes. Protein levels of E-Cadherin, α-SMA, Collagen 1, vimentin, and fibronectin in cell lysates of BRL-3A cells (a) and primary rat hepatocytes (c) were determined by a Western blot analysis. Relative protein levels were normalized to GAPDH (n = 6). Immunohistofluorescence analysis of E-Cadherin, α-SMA, Collagen 1, and vimentin in BRL-3A cells (b) and primary rat hepatocytes (d). Representative immunofluorescence images are shown (scale bar, 50 and 25 μm for BRL-3A cells, 75 μm for primary rat hepatocytes). The data are expressed as the mean ± SEM (n = 6). ^##P < 0.01, ^###P < 0.001 versus Normal-Control; ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus Fructose-Vehicle.

Fig. 9c

Relative cell lysate JAK2 mRNA levels (c) in miR-375-3p inhibitor-transfected BRL-3A cells were determined by qRT-PCR. The data are expressed as the mean ± SEM. ^###P < 0.001 versus Normal-Control; *P < 0.05, **P < 0.01 versus Fructose-Vehicle + miR-375-3p inhibitor negative control.