Fig. 3: ZBED6 silencing exacerbates cardiac fibrosis. | Acta Pharmacologica Sinica

Fig. 3: ZBED6 silencing exacerbates cardiac fibrosis.

From: Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation

Fig. 3: ZBED6 silencing exacerbates cardiac fibrosis.

a A schematic diagram of experimental design. b–d The expression of ZBED6 in ZBED6 silencing mice (shZBED6-V) and control mice (shNC-V). n = 5–6. **P < 0.01 vs. shNC-V. e Echocardiographs and statistics. f EF (%), g FS (%), h LVID;d (mm) and i LVID;s (mm). n = 5. *P < 0.05, **P < 0.01 vs. shNC-V; j The heart weight to body weight ratio in the two groups. n = 6. *P < 0.05 vs. shNC-V. k Representative images of Masson staining in ZBED6 knockdown mice. Scale bar = 50 μm. n = 4. l, m Immunofluorescence diagram of α-SMA in mouse hearts. Scale bar = 20 μm. n = 4. **P < 0.01 vs. shNC-V. n–q The mRNA expression levels of fibrosis-related genes in mice. n = 5. **P < 0.01 vs. shNC-V.

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