Fig. 9: Schematic diagram illustrating the mechanism by which ZBED6 attenuates cardiac fibrosis.

The transcriptional repressor ZBED6 inhibits the transcription of Piezo1, which blocks the nuclear translocation of YAP and its pro-fibrotic activity.

The transcriptional repressor ZBED6 inhibits the transcription of Piezo1, which blocks the nuclear translocation of YAP and its pro-fibrotic activity.