Correction to: Acta Pharmacologica Sinica https://doi.org/10.1038/s41401-026-01759-z, published online 27 February 2026

Corrections: The authors regret to report errors in the paper published. First, the title should be changed to “IG20/MADD gene functional isoform KIAA0358 can promote insulin secretion in glucose and repaglinide-induced pancreatic β-cells” instead of “IG20/MADD gene functional isoform KIAA0358 can promote glucose and insulin secretion in repaglinide-induced pancreatic β-cells”; Secondly, the significant difference icons of Figures 7c and 7e, which were previously duplicated with Figures 7f and 7g, and now there were changed to “& or &&&”. And correspondingly, the figure legends also have been changed to: &P < 0.05, &&&P < 0.001 vs. group of 0.75 μM KIAA0358.

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a Co-immunoprecipitation of SNAP25 with Syntaxin1 and VAMP2 in Min6 and Min6 IG20–/– cell lysates and quantitative analysis of the results from 3 independent experiments. b, d 2 μM MANT-GDP loaded GSTtagged Rab3A/Rab27A was added, and nucleotide exchange was triggered by adding 200 μM GTP and 0, 0.75, or 1.5 μM purified KIAA0358. The decrease of fluorescence was measured over time and normalized to fluorescence prior to KIAA0358 addition, and the results from three independent replicates. c, e The first-order rate constants (Kobs) for Rab3A/Rab27A nucleotide exchange were calculated under different concentrations of KIAA0358, and the catalytic activity increased in a concentration-dependent manner. n = 3. f Lysates from Min6 cells and Min6 IG20–/– cells infected with Ad-vector or Ad-KIAA0358 were incubated with GST-Rim2α beads, and GST-pulldown assays were performed to examine the interaction between Rab3A and Rim2α. Quantitative analysis of the results from three independent experiments. g Lysates from Min6 cells and Min6 IG20–/– cells infected with Ad-vector or Ad-KIAA0358 were incubated with GST-Slac-2a beads, and GST-pulldown assays were performed to examine the interaction between Rab27A and Slac-2a. Quantitative analysis of the results from three independent experiments. &P < 0.05, &&&P < 0.001 vs. group of 0.75 μM KIAA0358. *P < 0.05, **P < 0.01, ***P < 0.001 vs. group of Min6 cells; #P < 0.05, ###P < 0.001 vs. group of Min6 IG20–/– cells infected with Advector, unpaired two-way Student’s t test. Summary graphs shown as means ± SEMs.

It is important to note that these corrections do not alter the findings or conclusions of the paper. The overall interpretation and impact of the study remain unchanged.

The authors sincerely apologize for any inconvenience caused to the journal and its readers. They are grateful for the understanding and support of the editorial team and the readers in rectifying these errors.