Table 2 Colocalized loci identified by colocalization analysis.

From: Exploring the shared genetic architecture between periodontitis and cardiovascular disease

Trait pairs

Top SNP

Region

CHR:POS

Start-End

Functional annotation

P

CADD

PP.H3

PP.H4

PD-CVD

rs12577801

11p15.5

11:835877

828916-843097

UTR5

5.50E-07

1.363

0.018

0.256

PD-HTN

rs4841042

8p23.1

8:8807112

8020338-9486795

intergenic

4.30E-08

1.478

0.751

0.026

PD-MI

rs2746689

1p32.2

1:55354964

54391286-56339902

downstream

8.07E-09

4.478

0.626

0.009

PD-AS

rs12914385

15q25.1

15:78606381

77632340-79493215

intergenic

2.46E-12

2.976

0.109

0.852

PD-CHD

rs2746689

1p32.3

1:55354964

54391286-56339902

downstream

9.47E-07

4.478

0.127

0.732

PD-CHD

rs62412131

6q25.3

4:41021577

40987986-41143701

intronic

2.09E-07

1.689

0.626

0.009

PD-CHD

rs754748242

4p14

6:160307551

159325651-161118395

intergenic

1.01E-07

7.301

0.456

0.047

  1. PP.H3 posterior probability of H3, PP.H4 posterior probability of H4; the locus boundary was defined as “chromosome: start-end”, PD Periodontitis, CVD Cardiovascular disease, HTN Hypertension, MI Myocardial Infarction, AS Atherosclerosis, CHD Coronary heart disease.
  2. Lead SNP was the SNP with minimum P within the corresponding locus.
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