Table 1 Comparison of clinical characteristics based on clinical subtypes
From: Aggressive NK-cell leukemia: clinical subtypes, molecular features, and treatment outcomes
Characteristics | Subacute ANKL N=18 (range) | Classic ANKL N=95 (range) | P |
|---|---|---|---|
Gender, no. of patients (%) | 0.007 | ||
Male | 5 (27.78) | 59 (62.11) | |
Female | 13 (72.22) | 36 (37.89) | |
Median ALT, U/l (range) | 69.35 (12.00–311.00) | 108.00 (6.00–933.00) | 0.009 |
Median ferritin, mg/l (range) | 618.00 (184.00–2280.58) | 4330.00 (99.00–146,000.00) | <0.001 |
Median fibrinogen, g/l (range) | 2.27 (0.50–5.01) | 1.51 (0.24–5.48) | 0.038 |
TP53 mutation, no. of patients (%)a | 0.038 | ||
Positive | 0 (0.00) | 11 (37.93) | |
Negative | 8 (100.00) | 18 (62.07) | |
Median prodromal period, days (range) | 115 (90–450) | 15 (0–79) | <0.001 |
OS, days (range; all patients) | 213.5 (98–551) | 49 (8–1480) | <0.001 |
OS, days (range; non-transplant patients)b | 206 (98–551) | 44 (8–273) | <0.001 |
