Fig. 1: Cohesin complex gene mutations in de novo AML patients | Blood Cancer Journal

Fig. 1: Cohesin complex gene mutations in de novo AML patients

From: Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemia

Fig. 1Fig. 1

a The diagram of the associations in patients with cohesin gene mutations. The component gene mutations were almost mutually exclusive. The MLL/PTD was detected by polymerase chain reaction method. b The patterns and locations of cohesin gene mutations. c The frequencies and pairwise co-occurrence of genetic alterations in patients with cohesin gene mutations. d Kaplan–Meier survival curves for OS and DFS stratified by cohesin gene mutation status in the 286 de novo non-M3 adult AML patients who received standard intensive chemotherapy. e Graphical representations of clonal evolution of three cohesin gene-mutated patients. UPN 12 and UPN 5 had dominant clones with cohesin gene mutations, which retained at relapse. UPN 28 had a subclone with RAD21 mutation at diagnosis, which disappeared during follow-up

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