Table 1 Multivariate analysis of the disease-free survival and overall survival

From: Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemia

Variables

Disease-free survival

Overall survival

 

RR

95% CI

P value

RR

95% CI

 

P value

  

Lower

Upper

  

Lower

Upper

 

Total cohort (n = 286)

Agea

1.916

1.401

2.621

<0.001

2.462

1.755

3.453

<0.001

WBCb

1.356

0.983

1.871

0.063

1.552

1.096

2.198

0.013

Karyotypec

1.553

0.982

2.456

0.060

1.936

1.219

3.076

0.005

NPM1/FLT3-ITDd

0.260

0.121

0.560

0.001

0.240

0.097

0.592

0.002

CEBPA double mutations e

0.504

0.301

0.844

0.009

0.352

0.182

0.678

0.002

RUNX1 e

0.977

0.593

1.611

0.928

1.012

0.593

1.728

0.965

ASXL1 e

0.973

0.563

1.683

0.922

1.134

0.646

1.990

0.662

IDH2 e

0.845

0.518

1.377

0.498

0.490

0.260

0.924

0.028

Cohesin genee

0.487

0.256

0.926

0.028

0.489

0.242

0.992

0.047

SFe

1.992

1.252

3.171

0.004

1.702

1.006

2.879

0.048

TP53 e

1.512

0.817

2.797

0.188

1.697

0.916

3.146

0.093

  1. RR relative risk, CI confidence interval, SF splicing factor genes
  2. aAge > 50 years relative to age ≤ 50 years (the reference)
  3. bWBC > 50,000/μl vs. ≤50,000/μl
  4. cUnfavorable cytogenetics vs. others
  5. dNPM1+/FLT3-ITD− vs. other subtypes
  6. eMutated vs. wild type
Back to article page