Table 1 Gene set “Cell Cycle” was detected by GSEA as significantly up-regulated in RHOU quartile I versus IV

From: The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma

GSEA results summary

GeneSet

Cell cycle

Genes

ITGB3BP, NUP160, BTRC, POLE, ANAPC4, KIF18A, POLA2, MCM8, APITD1, CCND2, PSMA3, CEP290, ANAPC7, NUP43

Normalized Enrichment Score (NES)

1.48

Nominal p-value

0.03

FDR

0.031

  1. ITGB3BP overexpression induces apoptosis in cancer cells24; NUP160, NUP43, KIF18A, BTRC, APITD1, and CEP290 are required for correct mitosis, centrosome dynamics, and chromosome alignment25–30; POLE, POLA2, and MCM8 have extremely important roles in DNA replication and genome stability31–33; ANAPC4 and ANAPC7 have emerging roles in differentiation control, genomic stability and tumor suppression34; CCND2 enhances cell cycle progression and MM proliferation35 and PSMA3 is part of the proteasome complex and essential for protein degradation during cell cycle progression36.
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