Table 2 Gene set “DNA Repair” was detected by GSEA as significantly up-regulated in RHOU quartile I versus IV

From: The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma

GSEA results summary

GeneSet

DNA repair

Genes

NBN, REV1, POLR2K, POLE, DDB2, LIG3, OGG1, ATM, RAD50, BRCA1

Normalized Enrichment Score (NES)

1.60

Nominal p-value

0.00

FDR

0.00

  1. These genes are extremely important since they encode for proteins essential in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis37–44.
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