Fig. 2: Targeted sequencing detects IGH and MYC translocations. | Blood Cancer Journal

Fig. 2: Targeted sequencing detects IGH and MYC translocations.

From: A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5

Fig. 2

Circos plots of (a) IGH and (b) MYC translocations. Chromosomes involved in translocations are magnified to highlight regions and genes near breakpoints. c Breakpoints (vertical lines) of canonical IGH translocations within IGH locus. E3A2 and E3A1: 3’ enhancer elements downstream of IGHA2 and IGHA1 genes, respectively. Eμ: μ enhancer. Purple boxes: switch regions. Figure is to scale

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