Table 2 Patients’ characteristics

From: Combining carfilzomib and panobinostat to treat relapsed/refractory multiple myeloma: results of a Multiple Myeloma Research Consortium Phase I Study

 

n = 32 (%)

Age

 Median-years (range)

66 (50–76)

 ≥ 65

18 (56)

Sex

 Female

17 (53)

 Male

15 (47)

Ethnicity

 Caucasian

19 (59)

 African–American

12 (38)

 Hispanic

1 (3)

ECOG performance status

 0

6 (19)

 1

25 (78)

 2

1 (3)

MM subtype

 IgG

13 (41)

 IgA

8 (25)

 Light chain

9 (28)

 Missing

2 (6)

International staging system

 I

18 (56)

 II

3 (9)

 III

9 (28)

 Missing

2 (6)

Bone marrow infiltration

 Plasma cells, % median (range)

30 (1–90)

Prior lines of therapy, number

 Median, range

4 (1–8)

 Prior Bortezomib

29 (91)

  - refractory

17 (53)

 Prior Lenalidomide

29 (91)

  - refractory

10 (31)

 Prior pomalidomide

7 (22)

 Prior anti-CD38

4 (13)

 Prior autologous stem cell transplantation

30 (94)

Disease status at study entry

 Relapse and refractory

27 (84)

 Relapse

5 (16)

  1. ECOG Eastern Cooperative Oncology Group, MM multiple myeloma, Ig immunoglobulin, anti-CD38 daratumumab or isatuximab