Table 2 Frequency of IgH translocations, hyperdiploidy, and copy number variations and comparison between race

From: Molecular underpinnings of clinical disparity patterns in African American vs. Caucasian American multiple myeloma patients

Gene

Type

ALL, n (N = 68)

CA, n (N = 47)

% (n/N)

AA, n (N = 21)

% (n/N)

P-value*

4;14

Translocation

2

2

4.3

0

0

1

8;14

Translocation

2

2

4.3

0

0

1

11;14

Translocation

6

0

0

6

28.6

0.0005

14;16

Translocation

1

0

0

1

4.8

0.309

Hyperdiploidy

Chromosomal gain

34

24

51.1

10

47.6

1

amp(1q)

Amplification

13

6

12.8

7

33.3

0.091

del(1p)

Amplification

3

0

0

3

14.3

0.027

del(13q)

Amplification

21

15

31.9

6

28.6

1

del(17p)

Amplification

13

10

21.3

3

14.3

0.74

  1. AA African Americans; CA Caucasian Americans
  2. *Two sided Fisher’s test p = 0.05