Table 1 ABCB1 SNPs demonstrate significant association with clinical outcome in patients enrolled in GO arm of the randomized AAML0531 clinical trial
ABCB1 SNPs | Differences by ABCB1 genotypes within No-GO or GO arm | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
ABCB1 SNP_rs1045642 | No-GO ARM (rs1045642) | GO-ARM (rs1045642) | ||||||||
% ± 2SE% | % ± 2SE% | % ± 2SE% | p | p | % ± 2SE% | % ± 2SE% | % ± 2SE% | p | p | |
CC (N = 132) | CT (N = 244) | TT (N = 93) | CC vs. CT vs. TT | CC vs. CT+TT | CC (N = 128) | CT (N = 238) | TT (N = 102) | CC vs. CT vs. TT | CC vs. CT+TT | |
5 years OS | 63 ± 9% | 62 ± 6% | 70 ± 10% | 0.323 | 0.371 | 59 ± 9% | 66 ± 7% | 71 ± 10% | 0.123 | 0.068 |
5 years EFS | 50 ± 9% | 44 ± 6% | 48 ± 11% | 0.633 | 0.466 | 44 ± 9% | 55 ± 7% | 56 ± 10% | 0.073 | 0.022 |
CC (N = 91) | CT (N = 171) | TT (N = 64) | CC vs. CT vs. TT | CC vs. CT+TT | CC (N = 97) | CT (N = 182) | TT (N = 77) | CC vs. CT vs. TT | CC vs. CT+TT | |
5 years DFS from EOC1 | 56 ± 11% | 50 ± 8% | 55 ± 13% | 0.441 | 0.472 | 51 ± 10% | 62 ± 7% | 64 ± 11% | 0.126 | 0.044 |
5 years RR from EOC1 | 40 ± 11% | 47 ± 8% | 43 ± 13% | 0.378 | 0.278 | 45 ± 10% | 30 ± 7% | 28 ± 10% | 0.024 | 0.007 |
ABCB1 SNP_rs2235015 | No-GO ARM (rs2235015) | GO ARM (rs2235015) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
% ± 2SE% | % ± 2SE% | % ± 2SE% | p | p | % ± 2SE% | % ± 2SE% | % ± 2SE% | p | p | |
GG (N = 300) | GT (N = 141) | TT (N = 24) | GG vs. GT vs. TT | GG+GT vs. TT | GG (N = 295) | GT (N = 141) | TT (N = 27) | GG vs. GT vs. TT | GG+GT vs. TT | |
5 years OS | 64 ± 6% | 63 ± 8% | 66 ± 20% | 0.848 | 0.954 | 65 ± 6% | 68 ± 8% | 54 ± 20% | 0.450 | 0.247 |
5 years EFS | 46 ± 6% | 49 ± 9% | 41 ± 20% | 0.892 | 0.644 | 52 ± 6% | 55 ± 8% | 37 ± 19% | 0.303 | 0.156 |
GG (N = 212) | GT (N = 94) | TT (N = 16) | GG vs. GT vs. TT | GG+GT vs. TT | GG (N = 219) | GT (N = 111) | TT (N = 22) | GG vs. GT vs. TT | GG+GT vs. TT | |
5 years DFS from EOC1 | 52 ± 7% | 55 ± 10% | 49 ± 26% | 0.934 | 0.719 | 60 ± 7% | 60 ± 9% | 41 ± 21% | 0.286 | 0.118 |
5 years RR from EOC1 | 46 ± 7% | 40 ± 10% | 45 ± 27% | 0.851 | 0.929 | 33 ± 7% | 30 ± 9% | 59 ± 22% | 0.046 | 0.016 |
