Table 2 Summary and comparisons of demographic characteristics and serumfree lightchain (sFLC) values in 350 relatives, ages 50 and older at sample collection within 155 chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis (CLL/MBL) families vs. 15,396 Olmsted County controls
Family members | Controls | p-values | |||
|---|---|---|---|---|---|
MBL | Unaffected | MBL vs. controls | Unaffected vs. controls | ||
N | 87 | 263 | 15, 396 | ||
Age, mean (SE) | 68.4 (1.2) | 63.6 (0.7) | 63.9 (0.1) | <0.001 | 0.609 |
Female, N (%) | 43 (49.4%) | 178 (67.7%) | 8,529 (55.4%) | 0.264 | <0.001 |
sFLC sum, LS mean (SE) | 2.71 (1.05) | 2.57 (1.03) | 2.81 (1.00) | 0.423 | <0.001 |
κ, LSa mean (SE) | 1.34 (1.06) | 1.27 (1.03) | 1.24 (1.00) | 0.177 | 0.577 |
λ, LSa mean (SE) | 1.29 (1.05) | 1.26 (1.03) | 1.51 (1.00) | 0.001 | <0.001 |
rFLC (κ:λ), LSa mean (SE) | 1.04 (1.04) | 1.00 (1.03) | 0.82 (1.00) | <0.001 | <0.001 |
Age 50–59 (N) | 25 (28.7%) | 118 (44.9%) | 6,323 (41.1%) | ||
Elevated sFLC | 2 (8.0%) | 6 (5.1%) | 584 (9.2%) | 0.999 | 0.154 |
Polyclonal sFLC | 2 (8.0%) | 5 (4.2%) | 550 (8.7%) | 0.925 | 0.113 |
Monoclonal sFLC | 0 (0.0%) | 1 (0.8%) | 34 (0.5%) | 0.389 | 0.275 |
Age 60–69 (N) | 21 (24.1%) | 76 (28.9%) | 4,604 (29.8%) | ||
Elevated sFLC | 3 (14.3%) | 11 (14.5%) | 747 (16.2%) | 0.986 | 0.951 |
Polyclonal sFLC | 2 (9.5%) | 9 (11.8%) | 713 (15.5%) | 0.614 | 0.576 |
Monoclonal sFLC | 1 (4.8%) | 2 (2.6%) | 34 (0.7%) | 0.009 | 0.015 |
Age 70–79 (N) | 29 (33.3%) | 45 (17.1) | 3,121 (20.3%) | ||
Elevated sFLC | 9 (31.0%) | 9 (20.0%) | 810 (26.0%) | 0.898 | 0.329 |
Polyclonal sFLC | 7 (24.1%) | 8 (17.8%) | 775 (24.8%) | 0.612 | 0.251 |
Monoclonal sFLC | 2 (6.9%) | 1 (2.2%) | 35 (1.1%) | 0.012 | 0.250 |
Age 80 + (N) | 12 (13.8%) | 24 (9.1%) | 1,348 (8.8%) | ||
Elevated sFLC | 6 (50.0%) | 12 (50.0%) | 567 (42.1%) | 0.774 | 0.559 |
Polyclonal sFLC | 5 (41.7%) | 10 (41.7%) | 551 (40.9%) | 0.845 | 0.890 |
Monoclonal sFLC | 1 (8.3%) | 2 (8.3%) | 16 (1.2%) | 0.008 | 0.002 |
