Table 2 Treatment responses

From: Oprozomib in patients with newly diagnosed multiple myeloma

 

ORd

OCyd

OMP

 

5/14 Schedule, 150–210 mg OPZ N = 13

2/7 Schedule, 210 or 240 mg OPZ N = 5

2/7 Schedule, 210 mg OPZ N = 3

2/7 Schedule, 180 mg OPZ N = 7

Best overall response, n (%)

Stringent complete response

0

1 (20.0)

0

0

Complete response

2 (15.4)

0

0

1 (14.3)

Very good partial response

2 (15.4)

2 (40.0)

1 (33.3)

0

Partial response

4 (30.8)

1 (20.0)

2 (66.7)

2 (28.6)

Stable disease

1 (7.7)

0

0

3 (42.9)

Not evaluable

2 (15.4)

0

0

0

Missing or unknown

2 (15.4)

1 (20.0)

0

1 (14.3)

Overall response rate, %

61.5

80.0

100.0

42.9

  1. OCyd oprozomib, cyclophosphamide, and dexamethasone; OMP oprozomib, melphalan, and prednisone; OPZ oprozomib; ORd oprozomib, lenalidomide, and dexamethasone