Fig. 5: In CoMMpass, +1q21 corresponds with poor prognosis. | Blood Cancer Journal

Fig. 5: In CoMMpass, +1q21 corresponds with poor prognosis.

From: Gain of Chromosome 1q is associated with early progression in multiple myeloma patients treated with lenalidomide, bortezomib, and dexamethasone

Fig. 5

a Copy number alterations at the 1q21 locus in 870 myeloma samples from newly diagnosed patients in the CoMMpass study (IA13). Copy number is plotted as the log2 ratio of myeloma compared to normal from the same patient. Copy number thresholds are denoted by red lines and labeled (top). b Progression-free survival (PFS; left) and overall survival (OS; right) for patients with myeloma that has 2 × (gray; N = 575), 3 × (black; N = 242), and 4 × (red; N = 53) 1q21 copies. P-values indicate the difference in survival between 2×, 3×, and 4× 1q21 copies as determined using a Cox Proportional Hazards Wald test.

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