Fig. 1: miRAMM findings in a patient who was considered negative at the time of screening in 1997 but developed a monoclonal protein in 2012.

Top panel demonstrates an IgG kappa M-protein (23,400.1 Da) by miRAMM, also showing post-translational light-chain modification by glycation and glycosylation. Bottom panel in the same patient 15 years earlier, showing no evidence of monoclonal protein.