Fig. 1: Genomic location of MYC gene versus the various MYC FISH probes used for evaluation in B-cell malignancies.
From: High level MYC amplification in B-cell lymphomas: is it a marker of aggressive disease?
Genomic View of the MYC gene region on chromosome 8q24.1 (MYC gene highlighted by Black Arrow). Located underneath are boxes representing the 3 sets of MYC probes used in this study: First Row: Break-apart 5′ (Red)/3′ (Green) probe; Second Row MYC probe (Red) from the MYC/IGH D-FISH probe set; Third Row: MYC probe(Red) from the MYC/IGL D-FISH and MYC/IGK D-FISH probe sets. The Red and Green boxes are in the appropriate genomic location and indicate the genomic footprint of the individual probe. The MYC BAP probe and MYC/IGH D-FISH probes are Abbott Molecular and represented here with permission. The MYC/IGL and MYC/IGK D-FISH probes are Mayo laboratory developed probes.
