Table 1 Demographic and clinical characteristics of AML patients and healthy controls.
Demographic characteristics | Discovery Population (n = 2027) 338 AML cases and 1689 healthy controls | Replication Population (n = 2104) 316 AML cases and 1788 healthy controls | Overall Population (n = 4131) 654 AML cases and 3477 healthy controls |
|---|---|---|---|
AML cases | |||
Age (years) | 55.19 ± 15.12 | 56.91 ± 17.25 | 56.02 ± 16.20 |
Sex ratio (male/female) | 1.13 (179/159) | 1.29 (178/138) | 1.20 (356/297) |
Country of origin | |||
Spain | 257 | 97 | 354 |
Germany | 26 | 74 | 100 |
Italy | – | 145 | 145 |
Austria | 55 | – | 55 |
Presentation | |||
de novo (n, %) | 324 (95.86) | 285 (90.19) | 609 (93.12) |
Secondary (n, %) | 14 (04.14) | 31 (09.81) | 45 (06.88) |
Healthy controls | |||
Age (years)* | 56.10 ± 9.55 | 42.76 ± 11.76 | 49.57 ± 11.33 |
Sex ratio (male/female) | 1.07 (871/818) | 0.91 (848/937) | 0.98 (1719/1754) |
Country of origin | |||
Spain | 667 | 507 | 1174 |
Germany | 1000 | 1087 | 2087 |
Italy | – | 194 | 194 |
Austria | 22 | – | 22 |
