Table 3 Univariable Cox proportional hazard analysis of variables that affect progression-free survival and overall survival in patients with an exceptional response to therapy post ASCT.
PFS | OS | |||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age ≥65 vs. age <65 | 3.53 (1.36–9.05) | 0.02 | 1.97 (0.54–7.13) | 0.336 |
ISS 1 vs. 2/3 | 0.65 (0.28–1.55) | 0.334 | 1.06 (0.37–3.08) | 0.904 |
Male vs. female | 1.49 (0.71–3.17) | 0.296 | 2.47 (0.94–6.53) | 0.065 |
Plasma cell percentage at diagnosis ≥40% vs. <40% | 1.47 (0.66–3.27) | 0.329 | 0.99 (0.36–2.75) | 0.987 |
IgA vs. non-IgA monoclonal protein | 0.91 (0.31–2.63) | 0.859 | 0.24 (0.03–1.84) | 0.091 |
LDH >222 vs. normal | 0.82 (0.23–2.92) | 0.758 | 0.85 (0.13–3.32) | 0.837 |
Renal failure at diagnosis vs. no renal failure | 0.92 (0.15–3.20) | 0.913 | 4.74 (0–NR) | 0.114 |
IMID vs. non-IMID induction | 1.16 (0.52–2.61) | 0.719 | 1.47 (0.48–4.53) | 0.508 |
At day +100 post ASCT, CR vs. less than CR | 1.09 (0.50–2.37) | 0.82 | 1.83 (0.59–5.66) | 0.268 |
Best response CR vs. non-CR | 0.47 (0.21–1.05) | 0.081 | 0.90 (0.29–2.81) | 0.859 |
Disease progression vs. no disease progression | – | 2.13 (0.77–5.93) | 0.139 | |